She'll talk about her decision to stop chemotherapy treatment.
Vickey Phelan, Christy Moore and Mario Rosenstock will be among the guests on this weeks Late Late Show.
Vicky will talk to host Ryan Tubridy about her decision to stop chemotherapy treatment and look ahead to Christmas at home with her family.
There'll also be a Toy Show Appeal and a tribute to former Queen frontman Freddie Mercury, 30 years on from his death.