Kilos of cocaine and cannabis were discovered at premises in Mountmellick.
Gardaí have seized more than €12.8m worth of cocaine in Laois.
Gardaí from the Dublin Crime Response Team (DCRT), made the discovery while conducting an ongoing, intelligence led operation in Mountmellick, and a number of other locations on Tuesday evening.
Approximately 182kg of cocaine and 4kg of cannabis herb has been seized. The estimated value of drugs is in excess of €12.8 million.
Three men have been arrested and are currently detained under Section 2 of the Criminal Justice (Drug Trafficking) Act, 1996, at Garda stations in the Eastern Region.
Assistant Commissioner Paul Cleary, Dublin Metropolitan Region (DMR), says, "This intelligence-led operation conducted by the Dublin Crime Response Team (DCRT) has taken down the main supply network for cocaine and crack cocaine into West Dublin.
"This operation targeting the sourcing, preparation and distribution of substantial quantities of these illicit drugs, stopped them from entering our communities and is another significant blow to an Organised Criminal Group.”
Investigations are ongoing.