Over a quarter of premises are empty according to new a report.
An Offaly town has the second highest rate of vacant commercial properties in the country.
A new report from Geoview shows over a quarter of premises in Edenderry are empty.
The North Offaly town, which has a rate of 27.7%, is just behind Ballybofey on 29.2%.
Commercial vacancy rates have risen slightly across the country between June 2020 and June 2021.
Meanwhile, Laois recorded the largest decrease in commercial vacancy rates in the country in that time period.
The O Moore County now has a rate of 13%, just ahead of Westmeath at 12%, while it's 15.4% in Offaly.
The national average is 13.6%.
A fifth of premises in Athlone are vacant, with 15.4% of premises in Portarlington being empty.
One in eight business properties in the region are used for Accommodation and Food services.
Just one in 10 premises in Meath and Wexford are vacant, while Sligo had the highest rate at one in five.
Laois Chamber says the drop in vacant commercial properties is due to the council incentivising businesses to set up in the area.
CEO Caroline Hoffman says they need to build on the good work done so far:
Over 80 Jobs At Risk In Westmeath Tech Plant
Shannon Callows Farmers Demand Inclusion In Flood Management Group
Offaly Teachers Win National STEM Award
Appeal Lodged Against 600 Acre Laois Solar Farm Project
Government Funding To Benefit Midlands Historical Structures
Former GAA Referee Pleads Guilty To Indecent Assault
Laois TD Warns EU Plans Threaten Irish Neutrality
Almost One Million Cigarettes Seized In Offaly
Management Can Easily End Industrial Action - SIPTU
Westmeath Credit Union Manager Wins Lifetime Achievement Award
Midlands Readers Encouraged To Take Part in MS Readathon
Westmeath Town Strong Performer For Fibre Broadband
Ireland's Oldest Living Person With EB Publishes Autobiography
Fund Midlands Councils To Build Housing On Public Land - Simon Community
Midlands Councils Boost Environmental Enforcement Performance
Offaly Food Workers Launch Industrial Action
Public Consultation Taking Place In The Midlands
Man Due In Court Over Armed Pharmacy Robbery In Offaly
Offaly Man Appointed President Of EU Body
Rising Rents Affecting Midlands HAP Tenants