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The centre will provide accommodation for up to 168 asylum seekers.
A protest against a direct provision centre in Co. Offaly has been arranged for this Saturday.
Last week, the Department of Justice announced a new centre would open at the former Marian Hostel in Tullamore.
From early March, it will begin providing accommodation for up to 168 asylum seekers.
A Facebook group called "Tullamore says no to Inhumane Direct Provision" is planning to hold a protest in the town on Saturday morning.