Its incidence of the virus was more than double the national average.
Westmeath has the highest incidence rate of covid-19 in Ireland over Christmas - more than double the national average.
The latest figures from the Health Protection Surveillance Centre show the Lake County had a rate of 3,056 cases per 100,000 people.
Clare and Kilkenny make up the top three.
Laois has the fifth highest rate in the country, at 1,799, followed by Offaly at 1,729.
The median aged of those who contracted the virus in the midlands is 29.
5,494 cases of covid-19 were confirmed in the midlands over Christmas.
Westmeath was worst affected, with 2,713 infections recorded, followed by 1,464 in Laois, and 1,317 in Offaly.
That accounts for 8.5 per cent of the 65,044 cases reported in Ireland in the last week of 2021.
However, the true number of cases is expected to be higher.
The HSE estimates up to 150,000 infections may have escaped official confirmation, due to the high demand for PCR tests.
                            
            Median House Prices Rise In Midlands
        
            Literary Festival Kicks Off In Laois Tomorrow
        
            New Entrance To Laois Shopping Centre Gets Green Light 
        
            Midlands Winners For Family Carer Of The Year Announced 
        
            INTO Survey Reveals Job Vacancies In Over Half Of Special Schools 
        
            Offaly Mother Raises Almost €2k for Down Syndrome Ireland
        
            Laois TD Urges Stronger Support For Tillage Sector
        
            Midlands Agricultural Land Prices Surge 10% In A Year
        
            People Weren't Happy With The Choice - Spoil The Vote Campaign
        
            Cannonball Ireland Raises Over €2.2m For Children’s Charities
        
            Plans Submitted To Revive Fire Damaged Café In Laois
        
            Gardai Seek Help In Locating Hijacked Car In Midlands
        
            Ryanair CEO Pleased With Jump In Profits
        
            TDs Call To Deport Convicted Relatives In Ashling Murphy Case
        
            Former Mayor of Westmeath County Council Laid To Rest
        
            Cabinet to Consider Charges For Asylum Seekers In IPAS Centers
        
            Gardai Looking For Man Last Seen In Midlands
        
            Jobs Fair In Support Of Couriers To Take Place In Laois
        
            New ‘Give Take Return’ Recycling Pilot To Launch In Westmeath
        
            Muintir Na Tíre Honoured For 40 Years Of Community Service In Laois