The loss represents the end of Town's unbeaten streak in the First Division.
Athlone Town let a 2-0 lead slip in the SSE Airtricity First Division last night.
Despite being down by two goals at the break, Wexford clawed back in the second half to knock in three goals, claiming a 3-2 win over the midlanders at Athlone Town Stadium.
It means Town's unbeaten streak in the First Division has come to an end.
Dario Castelo's side return to LOI action in 10 days time, when they'll welcome fourth-placed Bray Wanderers to Athlone Town Stadium.