Adrian Carberry and Tommy Hewitt's side are looking for first league wins.
Athlone Town will look to back up their win in the FAI Cup when they play Galway United tonight.
The midlanders welcome John Caulfield's new side to Lissywoolen for a 7.45 kick off.
Elsewhere In the First Division, leaders Cabinteely are away to Bray Wanderers,
It's Drogheda United versus Cobh Ramblers, UCD to take on Wexford and Shamrock Rovers Two up against Longford Town.
League Of Ireland 1st division fixtures:
Bray v Cabinteely
Drogheda v Cobh
UCD v Wexford
Longford v Shamrock Rovers II
Premier Division:
St. Patricks Athletic v Waterford
MATCHDAY
— Athlone Town AFC (@AthloneTownAFC) September 4, 2020
We host Galway United tonight at Athlone Town Stadium.
Kick-off is at 7 45pm and we'll have updates on our Twitter page.#CmonTheTown pic.twitter.com/8eaa4poWHW
Meanwhile, Athlone Town ladies also continue their inaugural Women's National League campaign this weekend.
Tommy Hewett's charges take on Treaty United of Limerick at 7 O'Clock tomorrow evening.
They'll be looking for their first win since joining the league.
Women's National League fixtures:
Bohemians v Cork
Galway v Shelbourne
Wexford Youths v Peamount
more photos from peamount v Athlone Town pic.twitter.com/rd0wD3VY0X
— Athlone Town Afc Womens Official (@AfcAthlone) August 31, 2020