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Leo Cullen has made widespread changes to his starting team after a narrow victory over Munster.
Leinster head coach Leo Cullen had made 14 changes to his side for Monday's interprovincial derby against Ulster in the URC.
Athlone's Robbie Henshaw returns to a starting position, lining up at inside centre for his 82nd cap for the Blues.
Rob Russell is the only player retained in the starting line-up following the St Stephen's Day win over Munster at Thomond Park.
Jamison Gibson Park has been passed fit to play at scrum-half and will be partnered at out-half by Sam Prendergast.
Ulster welcome back Steven Kitshoff and Rob Herring to their line-up for the game at the RDS.