The game comes ahead of their upcoming qualifying campaign.
The Republic of Ireland U-21's will travel to face Wales in a friendly next month.
Jim Crawford's will play their Welsh counterparts at Colliers Park in Wrexham on March 26th.
The game is to be streamed live on Welsh FA's social media channels at 1pm on the day.
Several regulars in the side will be missing including Michael Obafemi, Will Smallbone and Nathan Collins.
Republic of Ireland U21 Manager Jim Crawford said:
“We’re really looking forward to this game and to be reunited with the players again. The camp will set the tone for what we’re looking for with the Under-21s for the upcoming campaign and we’ll be aiming for a positive performance and result against Wales.
“It’s an opportunity for us to embed our vision for the Under-21s team which is a confident and exciting team that plays possession-based football.
“We’ll miss the likes of the injured Nathan Collins, Michael Obafemi and Will Smallbone. They’ll be a great influence on our team when it comes to the qualifiers and we wish them all a speedy recovery, but this is a chance for the new faces to come in and gel with those players who featured with us in the last campaign and understand the standards that are required.”
“Like Ireland, Wales have a lot of talented players who have a pathway to the senior team so this has the makings of an exciting game. Players from both nations know good performances can increase their chances of a call-up to the senior team so they’ll be out to impress. This is a brilliant opportunity for us to show what our group is capable of.”
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