Leo Cullen has named his squad to face Northampton.
Leinster could hand as many as five European debuts to youngsters in tomorrow's champions Cup clash with Montpellier.
Jamie Osbourne makes his from the outset, coming in at outside centre.
On the bench, Vakh Abdaladze, Jack Dunne, Academy scrumhalf Cormac Foley and Scott Penny, are all in line to play their first games in the Heineken Champions Cup should they be introduced at the GGL Stadium.
The Leinster Rugby squad and staff will leave Dublin airport tomorrow morning, Friday, ahead of the late evening kick-off in France (8pm).
Leinster Matchday 23:
15. Jimmy O'Brien
14. Adam Byrne
13. Jamie Osborne
12. Ciarán Frawley
11. James Lowe
10. Ross Byrne
9. Jamison Gibson-Park
1. Cian Healy
2. Rónan Kelleher
3. Andrew Porter
4. Ryan Baird
5. James Ryan (c)
6. Max Deegan
7. Dan Leavy
8. Jack Conan
Replacements:
16. Dan Sheehan
17. Ed Byrne
18. Vakh Abdaladze
19. Devin Toner
20. Jack Dunne
21. Cormac Foley
22. Tommy O'Brien
23. Scott Penny
Referee: Wayne Barnes (RFU)