Three midlands county champions will play opposition from Kilkenny, Kildare, and Dublin this weekend.
The midlands counties' senior hurlers are in Leinster quarter final action this weekend.
Shinrone will be looking to progress in their first ever provincial campaign after winning their maiden county title.
They face Naas in Newbridge on Saturday afternoon at 1.30.
Castletown Geoghegan have a tricky task on Sunday.
They're in Nowlan Park to play Ballyhale Shamrocks where throw in is set for half one.
And Laois champions Clough/Ballacolla will be looking to knock Kilmacud Crokes out for a second consecutive season.
They meet in Parnell Park on Sunday afternoon and that game gets underway at 2.30.