Manchester City usurped them at the summit last night.
After Manchester City soared to the summit last night, Manchester United can reclaim top spot in the Premier League tonight if they beat Sheffield United.
Marcus Rashford is fit for United, but the visitors are without Irish defender John Egan, who is suspended.
United boss Ole Gunnar Solskjaer (pr: Sol-shar) says the club's board have been supportive of him even in the tough moments.
That game has an 8.15 kick off at Old Trafford.
At the same time, Everton host high flying Leicester City at Goodison Park.
At 6pm, Thomas Tuchel takes charge of Chelsea for the first time as they welcome Wolves to Stamford Bridge, while also at 6 o'clock, Burnley meet Aston Villa.
There's a 7.30 kick off for the match involving Brighton and Fulham.