Roger Federer and Dominc Thiem have also pulled out.
Four-time champion Rafael Nadal has withdrawn from the US Open tennis and announced he won't play again this season.
The Spaniard is still struggling with a foot injury which forced him to miss Wimbledon and the Olympics.
Nadal is the latest big name to pull out of the Grand Slam at Flushing Meadows, following Roger Federer and title holder Dominic Thiem.
Hola todos: quería comunicaros que desgraciadamente tengo que poner fin a la temporada 2021.
— Rafa Nadal (@RafaelNadal) August 20, 2021
Sinceramente llevo un año sufriendo mucho más de lo que debería con con mi pie y necesito tomarme un tiempo.