Conor Murray, Joey Carbery and Robert Baloucoune also come in.
Robbie Henshaw has been restored to Ireland's starting XV for their final November international against Argentina.
It's one of four changes made by Andy Farrell from the win over New Zealand a week ago.
Conor Murray and Joey Carberry are installed at half-back while Robert Baloucoune makes his first start on the right wing.
Tom O'Toole, Dan Sheehan, Craig Casey and Harry Byrne come onto the bench.
🎤 @SimonZebo on the mic...😂#TeamOfUs | #IREvARG pic.twitter.com/GMtz5bcvWe
— Irish Rugby (@IrishRugby) November 19, 2021
James Ryan assumes the captaincy in the absence of Johnny Sexton and is partnered in second row by Iain Henderson.
The front row of Andrew Porter, Ronan Kelleher and Tadgh Furlong is retained as is the backrow of Caelan Doris, Josh van der Flier and Jack Conan.
Starting XV:
15. Hugo Keenan
14. Robert Baloucoune
13. Garry Ringrose
12. Robbie Henshaw
11. James Lowe
10. Joey Carbery
9. Conor Murray
1. Andrew Porter
2. Ronan Kelleher
3. Tadhg Furlong
4. Iain Henderson
5. James Ryan
6. Caelan Doris
7. Josh van der Flier
8. Jack Conan
Replacements
16. Dan Sheehan
17. Cian Healy
18. Tom O’Toole
19. Tadhg Beirne
20. Peter O’Mahony
21. Craig Casey
22. Harry Byrne
23. Keith Earls