Dario Castelo's side begin their First Division campaign at home before two away games.
Athlone Town return to League of Ireland action as the domestic competition returns for 2024.
The midlanders made the promotion play-offs last season only to depart at the semi-final stage at the hands of now Premier Division, Waterford.
Wexford are providing the opposition for Dario Castelo's side this evening, and will be looking to repeat the 2-0 victory from their last visit to the Athlone Town Stadium in August.
Kick off is set for 7.45pm.
Elsewhere in the First Division Cork City play Kerry FC, UCD go to Bray Wanderers and Treaty United host Cobh Ramblers.
In the Premier Division, Shamrock Rovers will begin their attempt to win five titles in a row tonight.
The Hoops welcome Dundalk to Tallaght Stadium on the opening night of the new season. There is an 8pm kick off there.
The other matches kick off at 7.45.
Last year's runners up Derry City host Drogheda United.
There are two promoted clubs - last year's First Division winners Galway United are at home to St Pats - and the other promoted side - Waterford - take on Shelbourne.
The other match sees Bohemians and Sligo Rovers clash at Dalymount Park.